Volume 1 ; Issue 1 ; in Month : Jan-Dec (2019) Article No : 101
Good L, Panas RM

Abstract

For many patients with inflammatory bowel disease, the need for a proctocolectomy with the establishment of a J-pouch is a necessary procedure. In some patients, an inflammatory condition of the J-pouch known as pouchitis contributes to symptoms that include bloody diarrhea, urgency, dehydration and endoscopic evidence of inflammation. The specific cause of pouchitis is unknown, and there is also no universally accepted or FDA-approved treatment for pouchitis. As such, many patients are managed empirically with multiple medication regimens. Ten patients with pouchitis, who experienced flares and poor management of their condition with conventional drug treatments, had severe, unremitting chronic diarrhea. It was not until the addition of serum-derived bovine immunoglobulin/protein isolate (SBI) that 8 of 10 patients experienced satisfactory management of their pouchitis-associated diarrhea. An ongoing analysis of 7 of these 10 patients for up to 5 years found that 5 of these patients experienced ongoing management of their diarrhea associated with pouchitis with no reports of any flares with the remaining 2 patients reporting a few minor flares. One patient out of the 5 analyzed was able to discontinue all adjunctive therapies. Three of the 10 original patients were lost-to-follow up or moved out of state and no further details were available for ongoing analysis. As a medical food, SBI is not intended for the specific treatment of pouchitis, but these patients demonstrate beneficial effects in the long-term management of diarrhea-associated with pouchitis.

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